|
KMID : 0377619920570030187
|
|
Korean Jungang Medical Journal
1992 Volume.57 No. 3 p.187 ~ p.195
|
|
|
Effect of Food Restriction and Cyclophosphamide Administration on Immune Response in Mice
|
|
|
|
|
Abstract
|
|
|
|
It is important to know the correlation between food restriction and immune functions. However, very little research has been conducted on the effect of food restriction on immune functions and the underlying mechanism to account for the immunological alterations induced by limit-feeding is still not clear. In an attempt to understand better the effects of food restriction stress on immune response and to clarify such mechanism, the effect of food deprivation or water deprivation on cellular and humoral immune responses and the effect of cyclophosphamide (CY), a widely used antitumor drug, on the immunological alterations induced by fasting were studied. The cellular immune response was evaluated by delayedtype hypersensitivity (DTH) reactions to sheep red blood cells (SRBC) and contact hypersensitivity to dinitrofluorobenzene (DNFB). The humoral immune response was assessed by hemagglutinin response to SRBC. Mice were stressed by deprivation of food or water for 2 days before immunization. CY was given intraperitoneally as a single dose of 250 mg/Kg 2 days before immunization. The control mice were fed ad libitum both pellet and water. It was found that food deprivation for 2 days led to enhance Arthus reactions and 24-hr DTH reactions to SRBC. CY, given to food-deprived mice enhanced contact hypersensitivity to DNFB as well as Arthus and DTH reactions to SRBC. The water deprivation for 2 days also enhanced significantly the Arthus and DTH reactions. In contrast to cellular responses, food deprivation decreased hemagglutinin response, and the depressed antibody response by food deprivation stress was significantly reserved by CY injection. Taken together, these findings suggest that food restriction may enhance cell-mediated immunity but suppress antibody response in the applied experimental conditions and that CY-sensitive suppressor T cells may play an important role in the immunological alterations induced by stress.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|